Effect of Breast-Feeding on Oral Rhesus Rotavirus Vaccine Seroconversion: A Metaanalysis
- 1 September 1990
- journal article
- research article
- Published by Oxford University Press (OUP) in The Journal of Infectious Diseases
- Vol. 162 (3) , 753-755
- https://doi.org/10.1093/infdis/162.3.753
Abstract
The effect of concomitant breast-feeding on seroconversion following oral administration of rhesus rotavirus vaccine (RRV, serotype 3, strain MMU 18006) at 104 pfu was analyzed. Three studies were included, all randomized, double-blind trials involving a single dose of RRV to infants aged 2–5 months. None received concomitant oral polio vaccine. Seroconversion was measured by microneutralization or tube neutralization assay. The results show that 42 (48%) of 88 (95% confidence interval, 37%–58%) breast-fed babies seroconverted compared with 62 (70%) of 88 (95% confidence interval, 61%–80%) bottle-fed babies (χ2= 9.35, P < .005). Thus, there was a significant adverse effect of breast-feeding with respect to RRV vaccine seroconversion.Keywords
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