Pancreas Passage of Rous Sarcoma

Publisher Website
Google Scholar
Abstract
Serial intracoelomic passage of a strain of Rous sarcoma virus, obtained from Dr. W. Ray Bryan, National Cancer Institute, Bethesda, Maryland, showed the pancreas to be a novel, reliable source of virus for experimental purposes. Intracoelomic injection of pancreas-passed Rous sarcoma virus resulted in a relatively high and reproducible mortality in 8-day-old cockerels within a test period of 22 days. A significant regression in ED50 (P = 0.01) was observed over a series of 30 consecutive passages. The effect of the infection appeared to be a fulminating, ravaging disease, capable of invading and damaging almost any vital organ, with death as the end result.