Use of Polarized Light in Diagnosis of Mycotic Infections

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Abstract
Various pathogenic fungi such as Blastomyces dermatitidis, P. brasiliensis, Cryptococcus neoformans, Coccidioides immitis, etc., in histological sections from material included in paraffin when examined under polarized light appeared as anisotropic elements with a dark central cross surrounded by 4 luminous peripheral quadrants in a similar manner as monoaxial crystals. Protozoa, bacteria and virus inclusion bodies were isotropic. The use of polarized light is particularly useful in distinguishing between protozoa and fungi in paraffin sections, for instance Leishmania from Histoplasma.

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