Effect of Orally Administered Neomycin on the Absorption of Penicillin V

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Abstract
A TRANSITORY and reversible state of gastrointestinal malabsorption has been described during the oral intake of neomycin.1 2 3 4 5 Clinically and histopathologically this malabsorptive state is similar to that seen in nontropical sprue.4 , 5 The present communication reports the effect of orally administered neomycin on the gastrointestinal absorption of penicillin V (potassium phenoxymethyl penicillin) in 5 normal human subjects. Absorption of penicillin was studied by the bioassay of its concentrations in serum and urine before, during and after oral administration of neomycin, each subject serving as his own control.Materials and MethodsFive young, healthy male medical students served as volunteer subjects of . . .

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