Association of Group A Streptococci with an Outbreak of Cervical Lymphadenitis in Mice

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Abstract
Group A hemolytic streptococci were regularly isolated from the abscessed lymph nodes of Princeton mice during an outbreak of cervical lymphadenitis. The naturally acquired disease was reproduced in normal Princeton weanlings by nasal deposition of the organism in pure culture. The mortality rate was markedly increased, by nasal inhalation of the inoculum. In Swiss weanlings the morbidity rate of cervical lymphadenitis after deposition and the mortality rate after inhalation were much reduced. Nasal introduction of the streptococcus was attended by otitis media in 28 out of 45 Princeton weanlings (62%) and 40 out of 55 Swiss (72%).

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