Skin Radioprotection by 5-Thio-D-Glucose

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Abstract
The radioprotective effect of 5-thio-D-glucose on mouse skin was studied. Intraperitoneal injection of A/J mice with 1.5 g/kg of 5-thio-D-glucose 2 h prior to X irradiation of the foot reduced early foot skin damage through day 40 postirradiation by a dose modification factor of 1.3 .+-. 0.1. Similarly, late foot deformity during days 60-90 postirradiation was reduced by a factor of 1.2 .+-. 0.1. The radioprotective effect of 5-thio-D-glucose was also compared with that of WR-2721, an aminothiol radioprotector, in CDF1 mice. An i.p. injection of 1.5 g/kg of 5-thio-D-glucose reduced early radiation-induced skin damage by a dose modification factor of 1.2 .+-. 0.1 as compared to that of 1.5 .+-. 0.2 by 0.65 g/kg of WR-2721 in this strain of mice. 5-Thio-D-glucose specifically kills and radiosensitizes hypoxic tumor cells. This drug may be a useful radiotherapy adjuvant, reducing normal tissue damage and enhancing tumor control by minimizing hypoxic protection.