THE INFLUENCE OF A SINGLE HIGH DOSE OF OESTRADIOL BENZOATE ON THE ICSH-CONTENT IN THE SERUM OF GONADECTOMIZED MALE AND FEMALE RATS

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Abstract
A single injection of 50 [mu]g estradiol benzoate, administered at 11 a. m. to adult female rats which had been spayed 14 days previously and had since been treated with 0.5 [mu]g estradiol benzoate daily, led to an increase in the ICSH-content (interstitial cell stimulating hormone) of the serum, which was determined 29 hrs. after the injection. In an identical experimental design a decrease in the ICSH-content of the serum was found in adult male rats. ICSH-determinations were carried out by the ventral prostate assay. A stimulating effect upon the ventral prostate of estrogen present in the serum used for the above determinations was excluded. At the time when the changes in the serum were established, there were no demonstrable changes in the ICSH-content of the anterior pituitary gland in both sexes. The existence of a fundamental sex difference in the response to a single high dose of estrogen is suggested.