Studies on the nutritional basis of abnormal behavior in albino rats. III. The effect of different levels of vitamin B1 intake on convulsive seizures: the effect of other vitamins in the B-complex and mineral supplements on convulsive seizures.

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Abstract
A group of 25 animals was given ad lib. a diet free from vit. B1 and 5 [gamma] of this vit. administered by pipette daily to each animal; 3 other groups were given the same daily food allowance with 10, 15 and 50 [gamma]. Group V fed ad lib. and received 50 [gamma] per day of B1. Observations of seizures in response to a buzzer were made on alternate days. Frequency of seizures gradually increased to the 40th day, when food intake was limited to 5 g./day and the diet was further supplemented with other B vits., CaHPO4 and MgCl2, after which the frequency gradually decreased and remained low when the food was increased to 10 g. There may be a critical level of vit. B1 intake which results in maximum sensitivity. .... Both caloric intake and a deficiency of essential food substances are important factors in the etiology of sound-induced seizures in the rat.