How do microtubules guide migrating cells?
- 1 December 2002
- journal article
- research article
- Published by Springer Nature in Nature Reviews Molecular Cell Biology
- Vol. 3 (12) , 957-964
- https://doi.org/10.1038/nrm971
Abstract
Microtubules have long been implicated in the polarization of migrating cells, but how they carry out this role is unclear. Here, we propose that microtubules determine cell polarity by modulating the pattern of adhesions that a cell develops with the underlying matrix, through focal inhibitions of contractility.Keywords
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