Cytomegalovirus causes a latent infection in undifferentiated cells and is activated by induction of cell differentiation
Open Access
- 1 November 1981
- journal article
- research article
- Published by Rockefeller University Press in The Journal of Experimental Medicine
- Vol. 154 (5) , 1636-1651
- https://doi.org/10.1084/jem.154.5.1636
Abstract
Murine cytomegalovirus (MCMV) does not productively infect OTT6050AF1 BrdU, F9, or PCC4 undifferentiated murine teratocarcinoma cell lines, as shown by immunofluorescence assays for viral antigens and by plaque assays for infectious virus. However, these cells were infected by a variety of other viruses. MCMV does productively infect PYS2 and OTT F12 differentiated murine teratocarcinoma cell lines.This publication has 47 references indexed in Scilit:
- Mutation near the polyoma DNA replication origin permits productive infection of F9 embryonal carcinoma cellsCell, 1981
- A murine teratocarcinoma stem cell line carries suppressed oncogenic virus genomes.The Journal of Experimental Medicine, 1979
- The induction of differentiation in teratocarcinoma stem cells by retinoic acidCell, 1978
- Room temperature method for increasing the rate of DNA reassociation by many thousandfold: the phenol emulsion reassociation techniqueBiochemistry, 1977
- Resistance of teratocarcinoma stem cells to infection with simian virus 40: Early eventsJournal of Cellular Physiology, 1977
- Embryonal carcinoma cells (and their somatic cell hybrids) are resistant to infection by the murine parvovirus MVM, which does infect other teratocarcinoma-derived cell linesJournal of Cellular Physiology, 1977
- RNA-DNA hybridization in solution without DNA reannealingBiochemical and Biophysical Research Communications, 1977
- Pathogenesis of Cytomegalovirus Infection. Distribution of Viral Products, Immune Complexes and Autoimmunity During Latent Murine InfectionJournal of General Virology, 1976
- Neoplastic differentiation: Interaction of simian virus 40 and polyoma virus with murine teratocarcinoma cells in vitroJournal of Cellular Physiology, 1975
- ABSENCE OF SEROLOGICALLY DETECTABLE H-2 ON PRIMITIVE TERATOCARCINOMA CELLS IN CULTURETransplantation, 1974