A Method for Producing Sustained High Penicillin Levels in the Blood

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Abstract
Expts. on dogs showed that high aortic and peripheral blood penicillin levels could be achieved by the rapid intraven. injn. of large doses of conc. cryst. penicillin solns. into the right brachial v. In a human subject, adm. of 1 million U. of cryst. penicillin by the same method resulted in levels in the blood obtained from the descending arch of the aorta of 480, 346, 320 and 106.6 U./ml., resp., 1, 3, 5 and 10 min. after injn. Prolonged high penicillin levels in the peripheral blood were produced in human subjects by the same procedure along with the adm. of caronamide. When 1 million U. were adm. by this method every hr. for 10 hrs., levels > 200 U./ml. were maintained for > an hr. during the last hr. and 14 hrs. after the last injn. high levels were still present (13.0 and 5.7 U./ml.). Therapeutic implications are discussed.

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