Linkage graphs: a study in the thermodynamics of macromolecules
- 1 February 1984
- journal article
- research article
- Published by Cambridge University Press (CUP) in Quarterly Reviews of Biophysics
- Vol. 17 (4) , 453-488
- https://doi.org/10.1017/s0033583500004881
Abstract
In earlier papers (Wyman, 1975a, b, 1981) I have called attention to the existence of a group of linkage potentials derivable from one another by a corresponding group of Legendre transformations. These potentials are applicable to any system in a state of equilibrium but are especially useful in the study of the behaviour, or, as we may say, the functional chemistry, of a macromolecule in the presence of its ligands. In this paper I show how these potentials may be represented by a set of contour graphs which embody the results of observation and are transformable into one another by a group of graphical permutations equivalent to the Legendre group.Keywords
This publication has 19 references indexed in Scilit:
- The cybernetics of biological macromoleculesBiophysical Chemistry, 1981
- Kinetics of macromolecules reacting with ligandBiopolymers, 1980
- An analogue of the binding polynomial for the case of ligands binding to an aggregating macromoleculeJournal of Molecular Biology, 1980
- Metric geometry of equilibrium thermodynamics. V. Aspects of heterogeneous equilibriumThe Journal of Chemical Physics, 1976
- The turning wheel: a study in steady states.Proceedings of the National Academy of Sciences, 1975
- A group of thermodynamic potentials applicable to ligand binding by a polyfunctional macromolecule.Proceedings of the National Academy of Sciences, 1975
- Concerted changes in an allosteric macromoleculeBiophysical Chemistry, 1974
- On Allosteric ModelsPublished by Elsevier ,1972
- Allosteric LinkageJournal of the American Chemical Society, 1967
- The binding potential, a neglected linkage conceptJournal of Molecular Biology, 1965