Antiallergy activity of substituted 11-oxo-11H-pyrido[2,1-b]quinazoline-8-carboxylic acids
- 1 June 1979
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 22 (6) , 748-750
- https://doi.org/10.1021/jm00192a027
Abstract
A series of substituted 11-oxo-11H-pyrido[2,1-b]quinazoline-8-carboxylic acids were prepared and evaluated as antiallergy agents. Several analogs were orally active. 2-Methyl-11-oxo-11H-pyrido[2,1-b]quinoazoline-8-carboxylic acid was superior to cromolyn sodium and doxantrazole orally and i.v. in the rat PCA [passive cutaneous anaplylaxis] test and a rat allergic bronchospasm model.This publication has 3 references indexed in Scilit:
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