THE RESPONSE OF FEMALE MICE TO REPEATED INJECTIONS OF HUMAN CHORIONIC GONADOTROPHIN

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Abstract
A study was made of the response of female mice to 1, 6, 12, 18 and 24 days of treatment with 2 i.u. of human chorionic gonadotrophin daily. It was found that: ovulation in response to the exogenous hormone ceased between the 6th and the 12th day; between the 6th and the 18th day, the mice resumed normal oestrous cycles; the quality of eggs shed at natural oestrus during and after treatment was unimpaired, as judged by pregnancy examinations; the ability of the females to maintain pregnancy after treatment was similarly unimpaired; and during the period in which the females were responding to the exogenous hormone, they did not display the "Whitten effect". The results indicated that immunity had arisen to human chorionic gonadotrophin, but not to endogenous luteinizing hormone.