DIFFERENCE BETWEEN TWO INBRED STRAINS OF MICE IN OVULATORY RESPONSE TO REPEATED ADMINISTRATION OF GONADOTROPHINS

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Abstract
From 1 to 10 superovulations were induced in 116 BALB/c and 123 C57BR inbred mice by injections of pregnant mare''s serum and human chorionic gonadotropin at intervals of 4 days, 1 week or 2 weeks. It was found that: repeated superovulation elicited a refractoriness to the gonadotropins which was attained more quickly and more strongly in BALB/c mice than in C57BR mice; that this refractoriness was probably developed toward human chorionic gonadotropin rather than to pregnant mare''s serum; that mating could stimulate ovulation in hormone-primed mice which were refractory after 10 successively repeated superovulations.