A comparison of seven allocation rules for a clinical trial model
- 1 January 1986
- journal article
- research article
- Published by Taylor & Francis in Sequential Analysis
- Vol. 5 (3) , 193-221
- https://doi.org/10.1080/07474948608836100
Abstract
The risk in trial to compare two meical treatments is borne by patients who receive the inferior treatment during the experimental phase and by those remaining after the experiment who will all receive the inferior treatment if the results are misleading. An allocation rule s task is to balance these competing risks by deciding, during the course of the trial, when the experimental phase should be terminated. This paper compares the performance characteristics of various allocation rules that have been mentioned in the literature, and it seekds to correlate the structure of these and other allocation rules with their performance characteristics. Much use is made of computer based graphical techniques.Keywords
This publication has 5 references indexed in Scilit:
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- The Minimax Risk for Two-Stage Procedures in Clinical TrialsJournal of the Royal Statistical Society Series B: Statistical Methodology, 1985
- Sequential medical trialsProceedings of the National Academy of Sciences, 1980
- Modified Two-Armed Bandit Strategies for Certain Clinical TrialsJournal of the American Statistical Association, 1978
- Contributions to the "Two-Armed Bandit" ProblemThe Annals of Mathematical Statistics, 1962