Relation between Bronchial Reactivity to Antigen in Vivo and Serum IgE and IgG2a Antibody Levels in Rats
- 1 November 1982
- Vol. 37 (8) , 569-580
- https://doi.org/10.1111/j.1398-9995.1982.tb02342.x
Abstract
Sprague Dawley rats were immunized with graded doses of ovalbumin (OA) together with alum. The capacity of the animals to produce a bronchial anaphylactic response to i.v. antigen challenge was related to serum OA-IgE and OA-IgG2a antibody levels estimated by radioimmunoassay. A significant correlation between bronchial anaphylactic response capacity and OA-IgE antibody levels was found under a few, but not all, of several carefully chosen experimental conditions. No correlation was demonstrable between the in vivo reactivity of the animals and their serum levels of OA-specific IgG2a antibodies.Keywords
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