Crystal Structure of a Biosynthetic Sulfo-hirudin Complexed to Thrombin

This publication has 23 references indexed in Scilit:

• The natural mutation by deletion of Lys9 in the thrombin A‐chain affects the pK_a value of catalytic residues, the overall enzyme's stability and conformational transitions linked to Na⁺ binding
  The FEBS Journal, 2005
• A Natural Prothrombin Mutant Reveals an Unexpected Influence of A-chain Structure on the Activity of Human α-Thrombin
  Journal of Biological Chemistry, 2004
• Inhibition of human α-thrombin by a phosphonate tripeptide proceeds via a metastable pentacoordinated phosphorus intermediate
  Journal of Molecular Biology, 2001
• Human α-Thrombin Inhibition by the Active Site Titrant Nα-(N,N-dimethylcarbamoyl)-α-azalysine p-nitrophenyl ester: A Comparative Kinetic and X-ray Crystallographic Study
  Journal of Molecular Biology, 1996
• CX-397, a Novel Recombinant Hirudin Analog Having a Hybrid Sequence of Hirudin Variants-1 and -3
  Biochemical and Biophysical Research Communications, 1993
• Changes in interactions in complexes of hirudin derivatives and human α‐thrombin due to different crystal forms
  Protein Science, 1993
• Role of interactions involving C-terminal nonpolar residues of hirudin in the formation of the thrombin-hirudin complex
  Biochemistry, 1991
• Refined structure of the Hirudin-thrombin complex
  Journal of Molecular Biology, 1991
• The Structure of a Complex of Recombinant Hirudin and Human α-Thrombin
  Science, 1990
• Use of site-directed mutagenesis to investigate the basis for the specificity of hirudin
  Biochemistry, 1988