Comparison of Biokinetics and Biliary Imaging Parameters of Four Tc-99m Iminodiacetic Acid Derivatives in Normal Subjects

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Abstract
The biokinetics (blood clearance, urinary excretion, hepatic peak time, uptake and excretion t1/2 [half life]) and the imaging parameters (the time of appearance of the common bile duct, gallbladder and duodenum) were determined in 34 normal subjects using 99mTc diethyl (EIDA), 99mTc dimethyl (HIDA), 99mTc p-isopropyl (PIPIDA) and 99mTc p-butyl (PBIDA) iminodiacetic acid [IDA] derivatives. The blood and hepatic clearance of the 4 agents were significantly different (P < 0.05) from each other. The 24-h urinary excretion of PBIDA was significantly lower (P < 0.05) than the urinary excretion of the other 3 agents. There was no difference among the 4 agents in the time of appearance of the gallbladder and duodenum. The time of appearance of the common bile duct was significantly delayed with PBIDA. The maximum intensity of the common bile duct usually occurred between 20-40 min with all 4 agents. Gallbladder intensity continued to increase up to 3 h. In the presence of normal liver function, all 4 99mTc IDA agents show definite differences in biokinetics but these differences do not have a major effect on biliary imaging parameters. If imaging alone is the primary goal, the selection of any 1 of the 4 agents will meet the clinician''s need satisfactorily.