THE USE OF HYPERTONIC SUCROSE SOLUTION INTRAVENOUSLY TO REDUCE CEREBROSPINAL FLUID PRESSURE WITHOUT A SECONDARY RISE

Publisher Website
Google Scholar
Abstract
Spinal fluid pressures were measured aseptically for 1-13 hrs. on 31 dogs anesthetized with Na amytal. In 4 control exps. the pressure gradually rose during the period of observation. Intraven. injection of 50% glucose (3 exps.; 3 gm. per kgm.) and 30% NaCl (2 exps.; 0.61 and 1.64 gm. per kgm.) reduced the spinal fluid pressure for only 2-3 hrs.; the pressure then rose above the control level, exceeding it by 40 mm. (Ringer''s soln. (glucose)) and 110mm. (NaCl). Intraven.injection in 50% soln., of 3-8 gm. sucrose per kgm. body wt. reduced the pressure for 5-8 hrs.; the initial fall was 50-150 mm. Ringer''s soln. Even 12 hrs. after the injection, there was no indication of the beginning of a secondary rise in spinal fluid pressure exceeding the control level, except in 3 exps. In these it could be attributed to definite causes other than sucrose.