THE EFFECT OF INTRAVENOUS INJECTION OF SUCROSE AND GLUCOSE UPON THE REDUCING POWER OF CEREBROSPINAL FLUID, BEFORE AND AFTER HYDROLYSIS

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Abstract
Using the Folin micro-method for glucose but substituting speetrophotometric analyses for colorimetry (Duboscq) 12 normal spinal fluids from dogs yielded glucose values of 65-93 mgm. % (av. 77.5). Normal cerebrospinal fluid apparently contains no hydrolyzable reducing material, since the addition of NaCl, Na2SO4 or neutralized HC1 to known glucose solns. increases their reducing power to the same extent as that observed in normal spinal fluid after hydrolysis. Sucrose does not appear in definitely measurable amts. in the spinal fluid of dogs after intraven. injection of 3-6 gm. per kgm. body wt. Injection of 3-3.5 gm. glucose per kgm. is followed by marked hyper-glycorrhachia (187 mgm. %). The inability of sucrose to pass the blood-spinal-fluid barrier may account for the absence of the secondary rise in spinal fluid pressure when this substance is given intraven. in amts. sufficient to lower intracranial tension.