Veno-occlusive liver disease after dacarbazine therapy (DTIC) for melanoma
- 1 December 1984
- journal article
- research article
- Published by Wiley in Journal of Surgical Oncology
- Vol. 27 (4) , 268-270
- https://doi.org/10.1002/jso.2930270415
Abstract
A case of veno‐occlusive disease of the liver with fatal outcome after dacarbazine (DTIC) therapy for melanoma is reported. There was a fulminant clinical course from start of symptoms until death. At autopsy the liver was enlarged and firm with signs of venous congestion. Small and medium‐sized hepatic veins were blocked by thrombosis. Eosinophilic infiltrations were found around the vessels. Published cases from the literature are reviewed and pertinent features discussed.Keywords
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