Thyroid Function in Molar Pregnancy

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Abstract
Thyroid function was investigated in 6 patients with molar pregnancy by means of PBI [protein-bound iodine] (all 6 patients), resin uptake (2 patients) and I131-tracer test (1 patient). The PBI levels were found to be much higher than in normal pregnancies, whereas the resin uptakes were in the same range as those found in normal pregnancy. 1t1 I-tracer test showed a very high 1t1 I uptake, conversion ratio and secretion rate during the molar pregnancy. After evacuation of the moles the PBI levels, BMR [basal metabolic rate] and resin uptakes returned to nonpregnant values, whereas the 131I-tracer test showed a sudden decrease in the thyroid secretion rate. These studies indicate that during molar pregnancy hyperfunction of the thyroid gland exists. It is suggested that this hyperfunction might be due to the production of a thyrotrophic substance by molar tissue.

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