Synthesis of 10,11-Dihydro-12-oxo-LTB4, a Key Biochemical Intermediate
- 1 January 1997
- journal article
- research article
- Published by American Chemical Society (ACS) in The Journal of Organic Chemistry
- Vol. 62 (2) , 325-330
- https://doi.org/10.1021/jo9614957
Abstract
The first total synthesis of the 5(S)-hydroxy-10,11-dihydro-12-oxo-6(Z),8(E),14(Z)-eicosatrienoic acid (10,11-dihydro-12-oxo-LTB(4)) (3) is reported. This compound is a key pivotal intermediate in the biotransformation of LTB(4) by the so-called "LTB(4) reductase pathway".Keywords
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