Immunohistopathological studies of blastomycosis: the use of labeled specific antigens in a hamster model of disease
- 1 January 1984
- journal article
- research article
- Published by Springer Nature in Mycopathologia
- Vol. 85 (1-2) , 17-20
- https://doi.org/10.1007/bf00436697
Abstract
We applied a modified immunofluorescence and immunoperoxidase method, utilizing labeled Blastomyces dermatitidis antigens, to look for specific antibody-bearing B/ plasma cells in the tissue infiltrates of blastomycosis lesions induced in hamsters. No specific anti-blastomyces antibodies were detectable by this method, although such antibodies were present in blood samples as demonstrated by routine immunodiffusion techniques. These studies suggest that humoral immune reactions do not play a major role in the pathogenesis of lesions of blastomycosis in hamsters.This publication has 29 references indexed in Scilit:
- Immunohistochemistry with enzyme labeled antibodies: A brief reviewJournal of Immunological Methods, 1981
- Detection by Direct Immunofluorescence of Antibodies to Treponema pallidum in the Cutaneous Infiltrates of Rabbit SyphilomasThe Journal of Infectious Diseases, 1978
- Demonstration by Labeled Treponemal Antigen of Specific Antibodies in The Tissue Infiltrates of Secondary SyphilisJournal of Investigative Dermatology, 1977
- PEROXIDASE-LABELED ANTIBODY A NEW METHOD OF CONJUGATIONJournal of Histochemistry & Cytochemistry, 1974
- North American blastomycosis in Iowa review of 34 casesJournal of Chronic Diseases, 1973
- A NEW HYPOTHESIS ON THE EPIDEMIOLOGY OF BLASTOMYCOSIS AND THE ECOLOGY OF BLASTOMYCES DERMATITIDIS*Transactions of the New York Academy of Sciences, 1973
- NORTH AMERICAN BLASTOMYCOSISMedicine, 1968
- Experimental Cutaneous North American Blastomycosis of Hamsters**From the Clinical Laboratories, Jewish Hospital, and the Laboratory of Mycology, Departments of Dermatology and Pathology, Cincinnati General Hospital, Cincinnati, Ohio.Journal of Investigative Dermatology, 1965
- The application of fluorescent antibody techniques for the detection and identification of mycotic disease agentsMycopathologia, 1965
- Isolation of Blastomyces dermatitidis from SoilScience, 1961