Hypothalamic Norepinephrine: Circadian Rhythms and the Control of Feeding Behavior
- 10 November 1972
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 178 (4061) , 640-643
- https://doi.org/10.1126/science.178.4061.640
Abstract
The time of day is a decisive determinant of the effects of l-norepinephrine on feeding behavior. During the dark, direct application of l-norepinephrine to the hypothalamus of rats suppressed feeding behavior. During the light, treatment with the same dose of l-norepinephrine facilitated feeding behavior. Thus, l-norepinephrine has dual and opposite effects on feeding behavior. A hypothalamic substrate that fluctuates in a circadian rhythm could account for both actions of l-norepinephrine.Keywords
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