Urinary Alkalinization Induced by Choline

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Abstract
Urinary alkalinization following infusion of choline results primarily from an increased urinary bicarbonate output. Alkalinization of the urine also results in a decrease in ammonia output. It is argued that choline acts directly one the tubule in producing urinary alkalinization. In stop flow studies proximal secretion of choline has been confirmed, while in some experiments, results have indicated a possible reabsorption of choline at a distal site. A distal site continues to secrete acid under choline loading in the stop flow experiments, even when one would expect to find markedly alkaline urinary pH in a non-diuretic state. A model is presented which hypothesizes how choline may act to increase urinary pH and sodium reabsorption.

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