CD40-Associated TRAF 6 Signaling Is Required for Disease Induction in a Retrovirus-Induced Murine Immunodeficiency
- 1 June 2004
- journal article
- Published by American Society for Microbiology in Journal of Virology
- Vol. 78 (11) , 6055-60
- https://doi.org/10.1128/jvi.78.11.6055-6060.2004
Abstract
LP-BM5 retrovirus-infected C57BL/6 mice develop splenomegaly, lymphadenopathy, hypergammaglobulinemia, and immunodeficiency; thus, this disease has been named mouse AIDS. In this syndrome, CD154/CD40 interactions are required for but do not mediate disease by upregulation of CD80 or CD86. We report here that there is nonetheless a necessity for CD40 signaling competence, specifically an intact tumor necrosis factor receptor-associated factor 6 (TRAF 6) binding site.Keywords
This publication has 36 references indexed in Scilit:
- The CD154/CD40 Interaction Required for Retrovirus-Induced Murine Immunodeficiency Syndrome Is Not Mediated by Upregulation of the CD80/CD86 Costimulatory MoleculesJournal of Virology, 2002
- The B7 Family of Ligands and Its Receptors: New Pathways for Costimulation and Inhibition of Immune ResponsesAnnual Review of Immunology, 2002
- Cellular responses to murine CD40 in a mouse B cell line may be TRAF dependent or independentEuropean Journal of Immunology, 2002
- Characterization of the CD154-Positive and CD40-Positive Cellular Subsets Required for Pathogenesis in Retrovirus-Induced Murine ImmunodeficiencyJournal of Virology, 2001
- Mice transgenic for a soluble form of murine cytotoxic T lymphocyte antigen 4 are refractory to murine acquired immune deficiency sydrome developmentImmunology, 1999
- Studies on the interdependence of gp39 and B7 expression and function during antigen‐specific immune responsesEuropean Journal of Immunology, 1995
- Activated T cells induce expression of B7/BB1 on normal or leukemic B cells through a CD40-dependent signal.The Journal of Experimental Medicine, 1993
- A unique subset of normal murine CD4+ T cells lacking Thy‐1 is expanded in a murine retrovirus‐induced immunodeficiency syndrome, MAIDSEuropean Journal of Immunology, 1990
- Immunodeficiency and Clonal Growth of Target Cells Induced by Helper-Free Defective RetrovirusScience, 1989
- Functional T lymphocytes are required for a murine retrovirus-induced immunodeficiency disease (MAIDS).The Journal of Experimental Medicine, 1987