Synthesis of cyclic oligodeoxyribonucleotides via the ‘filtration’ approach
Open Access
- 1 January 1989
- journal article
- Published by Oxford University Press (OUP) in Nucleic Acids Research
- Vol. 17 (20) , 8221-8239
- https://doi.org/10.1093/nar/17.20.8221
Abstract
The synthesis of cyclic di-, tri-, tetra-, penta- and hexa-thymidylic acids (16; n = 2, 3, 4, 5 and 6) and the cyclic hexadeoxyribonucleotide [d(CpCpTpApGpGp)], via the "filtration" approach, is reported. Some of the physical properties of the cyclic oligonucleotides are discussed, and their susceptibility to digestion in the presence of phosphorylytic enzymes has been studied.Keywords
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