Studies on Urothelium. III. Experimental Vesical Stone Formation in the Dog

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Abstract
The contribution of mucopoly-saccharides to stone formation was studied histochemically in adult female dogs. Either fragments of human urinary calculi or silk sutures were placed in bladder pouches or the functioning bladder cavity as foreign bodies. The presence of increased amounts of intracellular paraaminosalicylic acid(PAS)-positive, diastase-resistant mucopoly-saccharide substance within the cytoplasm of transitional epithelium in cases of urolithiasis appears to be a secondary reaction rather than a pathogenic factor. Urine is necessary for the deposition of matrix or crystalloids within the bladder of the dog.