THE CONVERSION OF 11β-HYDROXYPROGESTERONE TO CORTICOSTERONE AND OTHER STEROID FRACTIONS BY RAT AND FROG ADRENAL GLANDS

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Abstract
Rat and frog adrenal glands incubated in Krebs-Ringer bicarbonate glucose solution convert added 11[beta]-hydroxyprogesterone to corticosterone more efficiently than added deoxycorticosterone. Up to 36% of the added 11[beta]-hydroxyprogesterone incubated with rat adrenal glands was accounted for by the increase in the corticosterone fraction. Adrenals from both animals also metabolized 11[beta]-hydro-xyprogesterone to fractions with the mobility of aldosterone and 18-hydroxyprogesterone. These findings suggest that 11[beta]-hydroxyprogesterone may play a significant role in corticoid synthesis.