Inhibition of hormone‐sensitive lipase by intermediary lipid metabolites
- 28 September 1992
- journal article
- Published by Wiley in FEBS Letters
- Vol. 310 (2) , 197-200
- https://doi.org/10.1016/0014-5793(92)81328-j
Abstract
Hormone-sensitive lipase (HSL) is inhibited in a non-competitive manner by oleoyl CoA, oleic acid and 2-monopalmitoylglycerol, 50% inhibition being observed at concentrations of approx. 0.1 μM, 0.5 μM and 500 μM, respectively. HSL is a key enzyme in lipid metabolism, mobilising triacylglycerol and cholesterol ester stores in several tissues. Feedback inhibition of HSL by oleoyl CoA and oleic acid may therefore prevent accumulation of free fatty acids and cholesterol in the cell, whereas 2-monoacylglycerol may act as a feedback inhibitor if the capacity of monoacylglycerol lipase is exceeded.Keywords
This publication has 23 references indexed in Scilit:
- Hormone-sensitive lipase and monoacylglycerol lipase are both required for complete degradation of adipocyte triacylglycerolPublished by Elsevier ,2002
- A common bicyclic protein kinase cascade inactivates the regulatory enzymes of fatty acid and cholesterol biosynthesisPublished by Wiley ,2001
- Hormone‐sensitive lipase is responsible for the neutral cholesterol ester hydrolase activity in macrophagesFEBS Letters, 1989
- Phosphorylation of bovine hormone‐sensitive lipase by the AMP‐activated protein kinaseEuropean Journal of Biochemistry, 1989
- Primary structure of the site on bovine hormone‐sensitive lipase phosphorylated by cyclic AMP‐dependent protein kinaseFEBS Letters, 1988
- Regulation of carboxyl ester lipase adsorption to surfaces. 1. Chemical specificityBiochemistry, 1987
- Hormone-sensitive lipase from bovine adipose tissueBiochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1986
- Cytosolic cholesterol ester hydrolase from bovine corpus luteumBiochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1983
- Direct Evidence that Cholesterol Ester Hydrolase from Adrenal Cortex is the Same Enzyme as Hormone‐Sensitive Lipase from Adipose TissueEuropean Journal of Biochemistry, 1982
- Inhibitory effects of long‐chain acyl coenzyme a analogues on rat liver acetyl coenzyme a carboxylaseFEBS Letters, 1979