Renal and endocrine response to water deprivation in dog

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Abstract
Plasma and urine Na, K, osmolality, aldosterone and plasma renin activity (PRA) were measured in time controls and during control dehydration and rehydration periods in conscious dogs fed a 50 mmol NaCl diet. During 4 days of H2O restriction, plasma Na and osmolality and PRA were elevated; plasma K and aldosterone were not affected. Urinary K excretion was elevated above intake levels during the entire dehydration period; Na excretion was only elevated during the first 2 days of dehydration. Unrestricted rehydration was associated with a marked fall in plasma K or aldosterone. In addition, during the 1st day of rehydration, there was marked retention of Na and K. Thus, in the dog, dehydration and subsequent rehydration cause significant alterations in Na and K balance and marked alterations in PRA that are not associated with changes in either plasma aldosterone concentration or urinary aldosterone excretion.