PROLONGED WATER DEPRIVATION IN THE DOG 1

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Abstract
Salt and water exchanges were studied in 4 dogs deprived of water and food for 11-20 days. The concs. of Na in serum rose 15-41 m.eq. per liter, indicating hypertonicity of body fluids. The total water loss greatly exceeded the extracellular water loss, indicating a substantial intracellular water loss. The intracellular water loss was differentiated into 3 processes: water lost on an osmotic basis, water lost with cell destruction in fasting, and water lost with K released in excess of nitrogen. The conc. of Na and Cl in urine diminished greatly, whereas that of K increased. The obligatory vaporization of water for the removal of heat entailed a loss of water without salt. Under a compulsion to lose base, the preferential excretion of K over Na increased intracellular water loss. The release of K mitigated, at the expense of cell fluid, not only the rise in total ionic conc. but also the depletion of extracellular vol.

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