Central serotonergic hyperresponsivity in late-onset Alzheimer's disease
- 1 November 1994
- journal article
- research article
- Published by American Psychiatric Association Publishing in American Journal of Psychiatry
- Vol. 151 (11) , 1701-1703
- https://doi.org/10.1176/ajp.151.11.1701
Abstract
The prolactin response to oral d-fenfluramine (30 mg) was measured in nine patients with late-onset Alzheimer's disease and in an elderly comparison group. The serotonin-mediated prolactin response was significantly greater in the patients with Alzheimer's disease than in the comparison group. This finding suggests that central serotonin responsivity is greater in Alzheimer's disease.Keywords
This publication has 12 references indexed in Scilit:
- Ritanserin attenuates anorectic, endocrine and thermic responses tod-fenfluramine in human volunteersPsychopharmacology, 1993
- Serotonergic dysfunction and aggression controlPsychological Medicine, 1991
- Serotonin, memory, and the aging brainPsychopharmacology, 1991
- Serotonin in Alzheimer‐type Dementia and Other Dementing IllnessesAnnals of the New York Academy of Sciences, 1990
- Effects of age and gender on CNS serotonergic responsivity in normal adultsBiological Psychiatry, 1990
- Hyperresponsivity to the Serotonin Agonist m-Chlorophenylpiperazine in Alzheimer's DiseaseArchives of General Psychiatry, 1989
- A post-mortem study of noradrenergic, serotonergic and GABAergic neurons in Alzheimer's diseaseJournal of the Neurological Sciences, 1988
- From Fenfluramine Racemate to d‐FenfluramineAnnals of the New York Academy of Sciences, 1987
- “Mini-mental state”Journal of Psychiatric Research, 1975
- Cerebral Blood Flow in DementiaArchives of Neurology, 1975