Cerebral blood flow, oxygen and glucose metabolism with PET in progressive supranuclear palsy
- 1 December 1989
- journal article
- case report
- Published by Springer Nature in Annals of Nuclear Medicine
- Vol. 3 (3) , 111-118
- https://doi.org/10.1007/bf03178296
Abstract
Cerebral blood flow, cerebral oxygen metabolic rate and cerebral glucose metabolic rate were measured with positron emission tomography (PET) in four patients with progressive supranuclear palsy (PSP). Decreased blood flow and hypometabolism of oxygen and glucose were found in both subcortical and cortical regions, particularly in the striatum including the head of the caudate nucleus and the frontal cortex. The coupling between blood flow and metabolism was preserved even in the regions which showed decreased blood flow and hypometabolism. These findings indicated the hypofunction, as revealed by decreased blood flow and hypometabolism on PET, both in the striatum and the frontal cortex, and which may underlie the pathophysiological mechanism of motor and mental disturbance in PSP.Keywords
This publication has 26 references indexed in Scilit:
- STEELE-RICHARDSON-OLSZEWSKI SYNDROMEBrain, 1988
- Design and Evaluation of a Positron Emission TomographJournal of Computer Assisted Tomography, 1985
- SUBCORTICAL DEMENTIABrain, 1985
- Alternative Approach to Single-Scan Estimation of Cerebral Glucose Metabolic Rate Using Glucose Analogs, with Particular Application to IschemiaJournal of Cerebral Blood Flow & Metabolism, 1984
- Correction for the Presence of Intravascular Oxygen-15 in the Steady-State Technique for Measuring Regional Oxygen Extraction Ratio in the Brain: 2. Results in Normal Subjects and Brain Tumour and Stroke PatientsJournal of Cerebral Blood Flow & Metabolism, 1983
- Computed Tomography and Positron Emission Transaxial Tomography Evaluations of Normal Aging and Alzheimer's DiseaseJournal of Cerebral Blood Flow & Metabolism, 1983
- Localization of Functional Activity in the Central Nervous System by Measurement of Glucose Utilization with Radioactive DeoxyglucoseJournal of Cerebral Blood Flow & Metabolism, 1981
- Quantitative Measurement of Regional Cerebral Blood Flow and Oxygen Metabolism in Man Using 15O and Positron Emission TomographyJournal of Computer Assisted Tomography, 1980
- THE [14C]DEOXYGLUCOSE METHOD FOR THE MEASUREMENT OF LOCAL CEREBRAL GLUCOSE UTILIZATION: THEORY, PROCEDURE, AND NORMAL VALUES IN THE CONSCIOUS AND ANESTHETIZED ALBINO RAT1Journal of Neurochemistry, 1977
- The `subcortical dementia' of progressive supranuclear palsyJournal of Neurology, Neurosurgery & Psychiatry, 1974