Environmental enrichment in adulthood promotes amblyopia recovery through a reduction of intracortical inhibition
Top Cited Papers
- 29 April 2007
- journal article
- Published by Springer Nature in Nature Neuroscience
- Vol. 10 (6) , 679-681
- https://doi.org/10.1038/nn1899
Abstract
Loss of visual acuity caused by abnormal visual experience during development (amblyopia) is an untreatable pathology in adults. We report that environmental enrichment in adult amblyopic rats restored normal visual acuity and ocular dominance. These effects were due to reduced GABAergic inhibition in the visual cortex, accompanied by increased expression of BDNF and reduced density of extracellular-matrix perineuronal nets, and were prevented by enhancement of inhibition through benzodiazepine cortical infusion.Keywords
This publication has 14 references indexed in Scilit:
- Critical period plasticity in local cortical circuitsNature Reviews Neuroscience, 2005
- Improving vision in adult amblyopia by perceptual learningProceedings of the National Academy of Sciences, 2004
- Decline of the Critical Period of Visual Plasticity Is Concurrent with the Reduction of NR2B Subunit of the Synaptic NMDA Receptor in Layer 4Journal of Neuroscience, 2003
- Reactivation of Ocular Dominance Plasticity in the Adult Visual CortexScience, 2002
- The present and potential impact of research on animal models for clinical treatment of stimulus deprivation amblyopiaClinical and Experimental Optometry, 2002
- Neural consequences of enviromental enrichmentNature Reviews Neuroscience, 2000
- Inhibitory threshold for critical-period activation in primary visual cortexNature, 2000
- BDNF Regulates the Maturation of Inhibition and the Critical Period of Plasticity in Mouse Visual CortexCell, 1999
- CRE-Mediated Gene Transcription in Neocortical Neuronal Plasticity during the Developmental Critical PeriodNeuron, 1999
- Local GABA Circuit Control of Experience-Dependent Plasticity in Developing Visual CortexScience, 1998