Retinal Lesions in Children Treated with Dideoxyinosine

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Abstract
Dideoxyinosine is a purine analogue with antiretroviral activity currently used to treat human immunodeficiency virus (HIV) infection.1 2 3 We recently reported the development of retinal lesions in 3 of 43 children (7 percent) with HIV infection treated with high doses of dideoxyinosine during a Phase I/II study of the drug.4 This prospective study has been expanded to include 95 children. We now report the development of similar retinal lesions in a fourth child during treatment with a lower dose of dideoxyinosine.