Molecular modelling studies on the non-covalent intercalative interactions between DNA and the enantiomers of anti-benzo[a]pyrene 7,8-diol-9,10-epoxide
- 1 January 1983
- journal article
- research article
- Published by Oxford University Press (OUP) in Carcinogenesis: Integrative Cancer Research
- Vol. 4 (2) , 211-215
- https://doi.org/10.1093/carcin/4.2.211
Abstract
The noncovalent intercalative interactions between a deoxydinucleoside model for DNA and the enantiomers of [carcinogen] anti-benzo[a]pyrenediol epoxide, were studied by molecular mechanics and computer graphics methods. Stereoselective differences between major and minor groove sites and between the enantiomers were found in terms of attractive close contacts.This publication has 28 references indexed in Scilit:
- Drug-nucleic acid interactions: conformational flexibility at the intercalation site.Proceedings of the National Academy of Sciences, 1978
- The reaction of trans-7,8-dihydroxy-anti-9,10-epoxy-7,8,9,10-tetrahydrobenzo(a)pyrene with DNA involves attack at the N7-position of guanine moietiesChemico-Biological Interactions, 1977
- Identification of the major adducts formed by reaction of benzo(a)pyrene diol epoxide with DNA in vitro.Proceedings of the National Academy of Sciences, 1977
- Structure of a dinucleoside phosphate–drug complex as model for nucleic acid–drug interactionNature, 1977
- Differences in mutagenicity of the optical enantiomers of the diastereomeric benzo[a]pyrene 7,8-diol-9,10-epoxidesBiochemical and Biophysical Research Communications, 1977
- Sequence specificity of mutagen-nucleic acid complexes in solution: Intercalation and mutagen-base pair overlap geometries for proflavine binding to dC-dC-dG-dG and dG-dG-dC-dC self-complementary duplexesProceedings of the National Academy of Sciences, 1977
- COMPARISON OF TUMOR-INITIATING ACTIVITIES OF BENZO(A)PYRENE ARENE OXIDES AND DIOL-EPOXIDES1977
- The reaction of (±)‐7α, 8β‐dihydroxy‐9β, 10β‐epoxy‐7,8,9,10‐tetrahydrobenzo(a)pyrene with dnaInternational Journal of Cancer, 1976
- Benzo[ a ]pyrene Diol Epoxides as Intermediates in Nucleic Acid Binding in Vitro and in VivoScience, 1976
- Identification of mutagenic metabolites of benzo(a)pyrene in mammalian cells.Proceedings of the National Academy of Sciences, 1976