Drug-nucleic acid interactions: conformational flexibility at the intercalation site.
- 1 February 1978
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 75 (2) , 828-832
- https://doi.org/10.1073/pnas.75.2.828
Abstract
Conformational features of the intercalation site in polynucleotides were examined. For all crystal structures of drug-dinucleoside complexes studied thus far, 2 torsion angles apparently differ from those found in A RNA (.vphi. and .chi., and alternate sugar puckering may not be prerequisite for intercalation. This intercalation geometry, which is the basis of helix axis displacement in a polymer, would necessitate conformational changes in adjacent nucleotides. The base-turn angle is less sensitive to conformation of the backbone than it is to small alterations in the base-pairing geometry. Apparently this angle is dependent on the nature of the intercalating drug.This publication has 12 references indexed in Scilit:
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