THE CENTRAL ROLE OF PYRUVATE IN THE STIMULATION OF SODIUM TRANSPORT BY ALDOSTERONE

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Abstract
The stimulation of sodium transport by aldosterone in the isolated urinary bladder of the toad Bufo marinus is specifically and markedly enhanced by pyruvate. In the presence of aldosterone, but not in its absence, small concentrations ([image]10-3 [image]) of pyruvate will induce prompt and sustained stimulation of sodium transport. Only pyruvate and, to a lesser extent, those substrates known to yield pyruvate during the course of their metabolism, i. e., glucose, lactate, and oxalacetate, have been found to possess this stimulatory effect in the aldosterone-treated bladder. Possible mechanisms for this effect of pyruvate are considered.