Amino Acids and Amines as Precursors of Epinephrine

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Abstract
Rat adrenals were depleted of epinephrine in 4 hrs. to the extent of 34% by insulin injn. No recovery occurred within a further 6 hrs. when rats were fed only glucose. Apparently the body cannot use its own nitrogenous compounds to synthesize epinephrine at an appreciable rate. Statistically significant recovery did occur when glucose feeding was supplemented by a complete diet, by amino acid mixture, or by dihydroxy-phenylalanine, but not when supplemented by phenylalanine, tyrosine, tyramine, phenylserine, synephrine, epinine, nor-epinephrine or even epinephrine itself. Results indicate that the adrenal cannot store epinephrine or nor-epinephrine from the blood.

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