ANTAGONISM OF METHIONINE IN AMINOSALICYLATE-INHIBITION OF MYCOBACTERIUM TUBERCULOSIS
- 1 April 1958
- journal article
- research article
- Published by American Society for Microbiology in Journal of Bacteriology
- Vol. 75 (4) , 417-421
- https://doi.org/10.1128/jb.75.4.417-421.1958
Abstract
Antagonism of methionine by structurally related amino acids was demonstrated in M. tuberculosis under conditions of para-aminosalicylic acid inhibition wherein an exogenous source of methionine was re-quired for restoration of growth. Methionine was antagonized by leucine, isoleucine, norleucine, norvaline, alanine, phenylalanine, tyrosine, threonine, and ornithine. Norleucine was the most effective single antagonist. The most effective antagonists were: isoleucine, norleucine, norvaline, and phenylalanine.Keywords
This publication has 9 references indexed in Scilit:
- MECHANISMS INVOLVED IN THE RESISTANCE OF MYCOBACTERIUM TUBERCULOSIS TO PARA -AMINOSALICYLIC ACID,Journal of Bacteriology, 1958
- ANTAGONISM OF THE INHIBITORY ACTION OF AMINOSALICYLIC ACID ON MYCOBACTERIUM TUBERCULOSIS BY METHIONINE, BIOTIN AND CERTAIN FATTY ACIDS, AMINO ACIDS, AND PURINESJournal of Bacteriology, 1956
- Studies on isoniazid and tubercle bacilli. III. The isolation, drug-susceptibility, and catalase-testing of tubercle bacilli from isoniazid-treated patients.Published by Elsevier ,1954
- Amino-acid utilization in bacterial growth. 1. Peptide utilization by a leucine-requiring mutant of Escherichia coliBiochemical Journal, 1953
- ANTAGONISM OF AMINO ACIDS IN THE GROWTH OF LACTIC ACID BACTERIAJournal of Biological Chemistry, 1948
- BIOCHEMICAL TRANSFORMATIONS AS DETERMINED BY COMPETITIVE ANALOGUE-METABOLITE GROWTH INHIBITIONSPublished by Elsevier ,1946
- THE MICROBIOLOGICAL DETERMINATION OF CERTAIN FREE AMINO ACIDS IN HUMAN AND DOG PLASMAJournal of Biological Chemistry, 1946
- BIOCHEMICAL TRANSFORMATIONS AS DETERMINED BY COMPETITIVE ANALOGUE-METABOLITE GROWTH INHIBITIONS .3. A TRANSFORMATION INVOLVING PHENYLALANINE1946
- Studies on the Nutrition and Metabolism of Pasteurella pestis.Experimental Biology and Medicine, 1943