The Large Scale Synthesis and Chromatographic and Spectral Properties of a Series of Alkylated Thymine and Uracil-Containing Nucleosides. O2-, 3- and O4-Alkylpyrimidine Derivatives

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Abstract
The syntheses of the O 2-, 3- and O 4-alkyl- (methyl-, ethyl-, n-propyl-and n-butyl-) deoxythymidines are described along with those of the methyldeoxyuridines and some alkyl-5-methyluridines. A simple direct alkylation procedure using the appropriate diazoalkane is used, followed by efficient chromatographic separations. These allow the compounds to be synthesised and purified in gram quantities if necessary. The chromatographic and UV spectral properties of the compounds are summarised together with their proton magnetic resonance spectra.

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