PROSTAGLANDIN-STIMULATED GASTRIC MUCUS SECRETION IN MAN

  • 1 January 1978
    • journal article
    • research article
    • Vol. 25  (4) , 292-294
Abstract
In 6 healthy volunteers, following intragastric instillation of a prostaglandin [PG] analog pentagastrin-stimulated gastric secretion of acid, pepsin and glycoprotein N-acetylneuraminic acid (NANA) was assessed. There was only a slight and statistically insignificant inhibition of acid output while pepsin secretion remained entirely unaffected. On the other hand, gastric mucus (NANA) secretion was significantly increased dependent on the PG dose administered. PG in addition to their well-known gastric acid inhibitory action may exert mucus stimulating properties and thus may have a direct protective effect on the gastric mucosa.