Studies on antimacrophage globulin.

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  • 1 May 1971
    • journal article
    • Vol. 8  (5) , 801-14
Abstract
The immunosuppressive and anti-inflammatory properties of rabbit antirat macrophage (AMG) and rabbit antirat thymocyte globulin (ALG) have been compared. In vitro experiments showed that both AMG and ALG contained antibodies directed against rat thymocytes and macrophages. When AMG was absorbed with large numbers of thymocytes, the final product was found to lack agglutinating and cytotoxic antibodies against such cells. However, AMG was cytotoxic to rat peritoneal macrophages at a dilution of 1/512 while the ALG cytotoxic titre was 1/64. It was also shown that AMG was able to suppress phagocytosis by peritoneal mononuclear cells while ALG was ineffective.