in vivo identification and monitoring of changes in rat brain glucose by two‐dimensional shift‐correlated 1h nmr spectroscopy
- 1 October 1992
- journal article
- research article
- Published by Wiley in Magnetic Resonance in Medicine
- Vol. 27 (2) , 356-361
- https://doi.org/10.1002/mrm.1910270216
Abstract
Intracerebral glucose resonance was directly detected and resolved in vivo by two-dimensional shift-correlated (COSY) 1H NMR spectroscopy in anesthetized rats (n = 4). The relative changes in brain glucose concentration were measured by volume integration of the α-D-glucose cross peak in the 2D COSY spectra. This report demonstrates the possibility of monitoring the variations in cerebral glucose following iv injection of glucose.Keywords
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