Effects of 2,3,7,8-Tetrachlorodibenzofuran (TCDF) on the Immune System in Guinea Pigs
- 1 January 1979
- journal article
- research article
- Published by Taylor & Francis in Drug and Chemical Toxicology
- Vol. 2 (1-2) , 49-60
- https://doi.org/10.3109/01480547908993181
Abstract
The effects of TCDF [2,3,7,8-tetrachloro-dibenzofuran] exposure on the immune system were investigated in Hartley guinea pigs. TCDF was administered by gavage at doses of 0.05, 0.17, 0.5 or 1.0 .mu.g/kg body wt once weekly for 6 wk. Thymus/body wt ratios were suppressed in the higher dosage groups. Parameters of cell-mediated and humoral immune function were investigated. TCDF modestly suppressed cell-mediated immune function and had slight effects on humoral-mediated functions. TCDF immunosuppression appears similar to that induced following exposure to TCDD.This publication has 12 references indexed in Scilit:
- Effect of polychlorinated biphenyls on the immune responses of rhesus monkeys and miceToxicology and Applied Pharmacology, 1978
- Studies on 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced immune suppression and decreased resistance to infection: Endotoxin hypersensitivity, serum zinc concentrations and effect of thymosin treatmentToxicology, 1978
- Impairment of thymus‐dependent immune functions by exposure of the developing immune system to 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin (TCDD)Journal of Toxicology and Environmental Health, 1977
- Toxicological assessment of hexachlorobiphenyl isomers and 2,3,7,8-tetrachlorodibenzofuran in chicksToxicology and Applied Pharmacology, 1976
- Determination of chlorinated dibenzofurans in Kanechlors and “Yusho Oil”Bulletin of Environmental Contamination and Toxicology, 1976
- Suppression of Cellular Immunity in Rats and Mice by Maternal Treatment with 2, 3, 7, 8-Tetrachlorodibenzo-p-DioxinInternational Archives of Allergy and Immunology, 1974
- The Measurement of Tuberculin Hypersensitivity in RatsInternational Archives of Allergy and Immunology, 1974
- PCB-induced suppression of the humoral and cell-mediated immunity in guinea pigsScience of The Total Environment, 1972
- Identification and toxicological evaluation of chlorinated dibenzofuran and chlorinated naphthalene in two commercial polychlorinated biphenylsFood and Cosmetics Toxicology, 1970