THE EFFECT OF SCANDIUM ON THE TISSUE DISTRIBUTION OF GA-67 IN NORMAL AND TUMOR-BEARING RODENTS

  • 1 January 1980
    • journal article
    • research article
    • Vol. 21  (4) , 361-365
Abstract
In rats and mice the i.v. administration of Sc before or with 67Ga produces an increase in 67Ga excretion and bone deposition, coupled with pronounced decreases in the uptake of 67Ga in soft tissues. The blocking by Sc of 67Ga plasma-protein binding sites forces into an unbound or loosely bound state. This increases 67Ga excretion and bone deposition, which acts to produce greatly reduced 67Ga uptake in soft tissues. When tumor-bearing rats and mice are administered Sc, similar effects occur, but the uptake of 67Ga by tumor tissue remains unchanged. 67Ga apparently enters tumor and normal soft tissues by different routes. With tumor, an unbound or loosely bound form of Ga is primarily involved, with normal soft tissues this route is apparently of minor importance.