RELATIONSHIPS AMONG DIFFERENTIATED T-CELL SUBPOPULATIONS .1. DISSOCIATED DEVELOPMENT OF TUBERCULIN TYPE HYPERSENSITIVITY, JONES-MOTE TYPE HYPERSENSITIVITY AND ACTIVATION OF HELPER FUNCTION

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  • 1 January 1976
    • journal article
    • research article
    • Vol. 31  (1) , 101-110
Abstract
Relationships among tuberculin type hypersensitivity, Jones-Mote type hypersensitivity and activation of helper T [thymus-derived] cells were studied in AKR mice by footpad reaction, migration inhibition test and antibody production against the trinitrophenyl group. Immunization with SRBC [sheep red blood cells] in saline, Freund''s incomplete adjuvant (FIA) or complete adjuvant (FCA), or with fixed-SRBC (FRBC) in FIA or FAC induced delayed hypersensitivity, as demonstrated by footpad swelling. Migration inhibition was positive in the groups immunized with SRBC or FRBC in FCA, but negative in those immunized with SRBC in saline or FIA or FRBC in FIA. This may suggest that the former has to be assigned to tuberculin type and the latter to Jones-Mote type. Pre-treatment with BCG and with cyclophosphamide (CY) augmented delayed footpad reaction in the mice immunized with SRBC in saline. Migration inhibition was positive only in the group pre-treated with BCG. BCG may convert the reaction from Jones-Mote type to tuberculin type, while CY may augment the reaction of Jones-Mote type. FRBC in saline scarcely induced delayed footpad reaction, whereas they activated helper function efficiently. Three types of immunological phenomena attributable to the functions of T cells may depend upon distinct subpopulations of differentiated T cells which are raised by different methods of immunization.

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